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Image Search Results
Journal: Oncotarget
Article Title: Mapping heterogeneity in patient-derived melanoma cultures by single-cell RNA-seq
doi: 10.18632/oncotarget.13666
Figure Lengend Snippet: ( A ) Gene expression levels of 4 cyclin-dependent kinases (CDK1, CDK2, CDK4 and CDK6) are analyzed for each of the 3 identified main groups. Data are given as standard box plots. CDK2 and CDK4 are consistently highly expressed in all groups. Positions of each CDK gene are shown on the mean SOM expression landscape indicated by arrows. ( B ) Growth inhibition curves are shown for treatments of a patient-derived melanoma short-term culture using inhibitors directed against CDK2 (purvanolol), CDK4 palbociclib, activated BRAF (vemurafenib), ERK1/2 (SCH772984), and MEK1/2 (cobimetinib).
Article Snippet: The following small molecule inhibitors were used:
Techniques: Gene Expression, Expressing, Inhibition, Derivative Assay